FAQs

Frequently Asked Questions

What are my CD4+ and viral load numbers?

What are my current HIV treatment goals?

What other HIV medicines will I be taking?

Will other medicines I am taking interfere with EDURANT® treatment?

How will I know if my treatment is working?

What is my dosing schedule?

What should I do if I have side effects?

What if I want to become pregnant?

How can I remember to take my medicine?

Where can I get additional support?

What are my CD4+ and viral load numbers?

To determine the number of CD4+ cells in your body, your healthcare professional will do a simple blood test called a CD4+ cell count. This test is used to keep track of how well treatment is working. Your healthcare professional will probably perform this test regularly during your treatment.

Your healthcare professional will also measure the amount of HIV in your blood. This is called your viral load. As HIV progresses, the amount of HIV in the blood—the viral load—will increase. The viral load test will help to decide how well treatment is working.

What are my current HIV treatment goals?

Two important goals of treatment for people with HIV are to:

  • Increase your CD4+ cell count
  • Keep your viral load (the amount of HIV in your blood) as low as possible increasing your CD4+ cell count and reducing the amount of HIV in your blood may make your immune system stronger. As a result, this may reduce the risk of serious problems that can happen when your immune system is weak

What other HIV medicines will I be taking?

EDURANT® must be taken in combination with other HIV medicines. Your healthcare professional will work with you to find the right combination of HIV medicines.

Will other medicines I am taking interfere with EDURANT® treatment?

EDURANT® may affect the way other medicines work and other medicines may affect how EDURANT® works and may cause serious side effects. If you take certain medicines with EDURANT®, the amount of EDURANT® in your body may be too low and it may not work to help control your HIV infection, and the HIV virus in your body may become resistant to EDURANT® or other HIV medicines that are like it. To help get the right amount of medicine in your body, you should always take EDURANT® with a meal.

How will I know if my treatment is working?

EDURANT® blocks an enzyme in the body called HIV reverse transcriptase. HIV needs this enzyme to make more virus. When this enzyme is blocked, less virus is made in your body. When used with other HIV medicines, EDURANT® may help:

  • Reduce the amount of HIV in your blood (your viral load)
  • Increase the number of CD4+ cells in your blood that help fight infection reducing the amount of HIV (your viral load) and increasing the CD4+ (T) cells in your blood may help improve your immune system. This may reduce your risk of death or getting infections that can happen when your immune system is weak (opportunistic infections)

What is my dosing schedule?

  • Stay under the care of your doctor during treatment with EDURANT®
  • Take EDURANT® every day exactly as prescribed by your doctor
  • Always take EDURANT® with a meal. Taking EDURANT® with a meal is important to help get the right amount of medicine in your body. A protein drink alone does not replace a meal
  • Do not change your dose or stop taking EDURANT® without first talking with your doctor. See your doctor regularly while taking EDURANT®
  • When your supply of EDURANT® starts to run low, get more from your doctor or pharmacy. It is important not to run out of EDURANT®. The amount of HIV in your blood may increase if the medicine is stopped even for a short time
  • If you miss a dose of EDURANT® within 12 hours of the time you usually take it, take your dose of EDURANT® with a meal as soon as possible. Then, take your next dose of EDURANT® at the regularly scheduled time. If you miss a dose of EDURANT® by more than 12 hours of the time you usually take it, wait and then take the next dose of EDURANT® at the regularly scheduled time
  • Do not take more than your prescribed dose to make up for a missed dose
  • If you take too much EDURANT®, go to your local emergency room right away

Do not stop taking EDURANT® or any other medicines without first talking to your healthcare professional. These are not all of the possible side effects with EDURANT®. For more information, ask your doctor or pharmacist.

What should I do if I have side effects?

Tell your doctor if you have any side effect that bothers you or does not go away.

The most common side effects of EDURANT® include depression, headache, trouble sleeping (insomnia) and rash.

These are not all of the possible side effects with EDURANT®. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects.

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088. You may also report side effects to Janssen Products, LP, at 1-800-JANSSEN (1-800-526-7736).

What if I want to become pregnant?

If you are pregnant or plan to become pregnant, it is not known if EDURANT® will harm your unborn baby. Tell your healthcare professional if you become pregnant during treatment with EDURANT®.

There is a pregnancy registry for women who take EDURANT® during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk with your healthcare professional about how you can take part in this registry.

Before taking EDURANT®, tell your doctor if you:

  • Are breastfeeding or plan to breastfeed. Do not breastfeed if you take EDURANT®. You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. It is not known if EDURANT® passes into your breast milk. Talk with your healthcare professional about the best way to feed your baby during EDURANT® treatment

How can I remember to take my medicine?

  • Connect your pills with something you do every day. EDURANT® must be taken with a meal, so plan to take it with breakfast, lunch, or dinner every day
  • Keep your pills in a pillbox and carry them with you when you go out. This way, wherever you are, you’ll always have them handy
  • Use computer reminders, telephone reminders, and watches, anything that trains you to remember. Forgetting is the most common reason for missing pills
  • Place a reminder note near something you use every day—your refrigerator or television, for example. When you see your note, you’ll remember to take your medicine
  • Make an appointment with a treatment counselor for support. Talking to a professionally trained counselor can make things easier

Do not stop taking EDURANT® or any other medicines without first talking to your healthcare professional.

Where can I get additional support?

Janssen CarePath

Janssen CarePath offers resources and support that may help you get started and stay on track with EDURANT® treatment as prescribed by your doctor. Call a Janssen CarePath Care Coordinator at 1-866-836-0114, Monday-Friday 8:00 am to 8:00 pm ET or visit www.JanssenCarePath.com.

Janssen CarePath Savings Program for EDURANT®

Eligible patients using commercial or private insurance can save on out-of-pocket costs for EDURANT®. Eligible patients pay $0 per fill, up to a $7,500 maximum program benefit per calendar year. Patients using Medicare, Medicaid, or other government-funded programs to pay for their medications are not eligible to participate. Terms expire at the end of each calendar year and may change. There is no income requirement. See full eligibility requirements at JanssenCarePathSavings.com or call Janssen CarePath at: 1-866-836-0114.

Janssen Therapeutics Medical Information

Janssen Therapeutics Medical Information is committed to providing current, accurate, and unbiased medical information about our products. If you have a question regarding our products, please call us at 1‐800‐JANSSEN(1‐800‐526‐7736). If you need to report a possible adverse event or product quality complaint, please call us immediately at 1‐800‐JANSSEN (1‐800‐526‐7736).

Important Safety Information

Who should not take EDURANT®?

Do not take EDURANT® if you also take:

  • anti-seizure medicines:
    • carbamazepine
    • oxcarbazepine
    • phenobarbital
    • phenytoin
  • anti-tuberculosis (anti-TB) medicines:
    • rifampin
    • rifapentine
  • proton pump inhibitor (PPI) medicine for certain stomach or intestinal problems:
    • esomeprazole
    • lansoprazole
    • omeprazole
    • pantoprazole sodium
    • rabeprazole
  • more than 1 dose of the steroid medicine dexamethasone or dexamethasone sodium phosphate
  • St. John’s wort (Hypericum perforatum)
  • What should I tell my healthcare professional before taking EDURANT®?

    Before taking EDURANT®, tell your healthcare professional about all your medical conditions, including if you:

  • have or had liver problems, including hepatitis B or C virus infection
  • have kidney problems
  • have ever had a mental health problem
  • are pregnant or plan to become pregnant. It is not known if EDURANT® will harm your unborn baby. Tell your healthcare professional if you become pregnant during treatment with EDURANT®
  • are breastfeeding or plan to breastfeed. Do not breastfeed if you take EDURANT®
    • You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.
    • It is not known if EDURANT® passes into your breast milk. Talk with your healthcare professional about the best way to feed your baby during EDURANT® treatment.

Tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Some medicines interact with EDURANT®. Keep a list of your medicines to show your healthcare professional and pharmacist when you get a new medicine. You can ask your healthcare professional or pharmacist for a list of medicines that interact with EDURANT®.

Do not start taking a new medicine without telling your healthcare professional. Your healthcare professional can tell you if it is safe to take EDURANT® with other medicines.

How should I take EDURANT®?

  • Take EDURANT® every day exactly as your healthcare professional tells you to.
  • Take EDURANT® 1 time each day with a meal. A protein drink alone does not replace a meal.
  • Do not change your dose or stop taking EDURANT® without first talking with your healthcare professional. Stay under the care of your healthcare professional during treatment with EDURANT®.
  • Do not miss a dose of EDURANT®.
  • If you take an H2-receptor antagonist (famotidine, cimetidine, nizatidine, or ranitidine), you should take these medicines at least 12 hours before or at least 4 hours after you take EDURANT®.
  • If you take antacids, or other products that contain aluminum, calcium carbonate, or magnesium hydroxide, you should take these medicines at least 2 hours before or at least 4 hours after you take EDURANT®.
  • If you miss a dose of EDURANT® within 12 hours of the time you usually take it, take your dose of EDURANT® with a meal as soon as possible. Then, take your next dose of EDURANT® at the regularly scheduled time. If you miss a dose of EDURANT® by more than 12 hours of the time you usually take it, wait and then take the next dose of EDURANT® at the regularly scheduled time.
  • Do not take more than your prescribed dose to make up for a missed dose.
  • If you take too much EDURANT®, call your healthcare professional or go to the nearest hospital emergency room right away.
  • When your supply of EDURANT® starts to run low, get more from your healthcare professional or pharmacy. It is important not to run out of EDURANT®. The amount of HIV in your blood may increase if the medicine is stopped even for a short time.
  • When your healthcare professional prescribes use of EDURANT® with oral VOCABRIA (cabotegravir):
    • Take EDURANT® and oral VOCABRIA (cabotegravir) once a day at approximately the same time with a meal.
    • You will receive treatment with EDURANT® tablets in combination with oral VOCABRIA (cabotegravir) tablets for one month (at least 28 days) before you receive the long-acting medicine called CABENUVA (cabotegravir; rilpivirine extended-release injectable suspensions) for the first time. This will allow your healthcare professional to assess how well you tolerate these medicines.
    • Your final dose of EDURANT® and oral VOCABRIA should be taken on the same day you receive your first CABENUVA injections.
  • What are the possible side effects of EDURANT®?

    EDURANT® can cause serious side effects including:

  • Severe skin rash and allergic reactions. Skin rash is a common side effect of EDURANT®. Skin rash can be serious. Call your healthcare professional right away if you get a rash. In some cases, rash and allergic reaction may need to be treated in a hospital.

    If you get a rash with any of the following symptoms, stop taking EDURANT® and get medical help right away:

    • fever
    • skin blisters
    • mouth sores
    • redness or swelling of the eyes (conjunctivitis)
    • swelling of the face, lips, mouth, tongue, or throat
    • trouble breathing or swallowing
    • pain on the right side of the stomach (abdominal) area
    • dark-colored urine “tea colored”

  • Change in liver enzymes. People with a history of hepatitis B or C virus infection or who have certain liver function test changes may have an increased risk of developing new or worsening liver problems during treatment with EDURANT®. Liver problems have also happened during treatment with EDURANT® in people without a history of liver disease. Your healthcare professional may need to do tests to check your liver enzymes before and during treatment with EDURANT®.
  • Depression or mood changes. Tell your healthcare professional right away if you have any of the following symptoms:
    • feeling sad or hopeless
    • feeling anxious or restless
    • have thoughts of hurting yourself (suicide) or have tried to hurt yourself
  • Changes in body fat can happen in people who take HIV medicine. These changes may include increased amount of fat in the upper back and neck (“buffalo hump”), breast, and around the middle of your body (trunk). Loss of fat from the legs, arms, and face may also happen. The exact cause and long-term health effects of these problems are not known.
  • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your healthcare professional right away if you start having any new symptoms after starting your HIV-1 medicine.

The most common side effects of EDURANT® include depression, headache, trouble sleeping (insomnia), and rash.

This is not a complete list of all side effects. If you experience these or other symptoms, contact your healthcare professional right away.

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/ medwatch, or call 1-800-FDA-1088. You may also report side effects to Janssen Products, LP, at 1-800-JANSSEN (1-800-526-7736).

Please read the full Product Information in PDF format for more details.

cp-51056v3

What is EDURANT® (rilpivirine)?

EDURANT® is a prescription medicine that is used with:

  • other antiretroviral medicines to treat Human Immunodeficiency Virus (HIV-1) in people 12 years of age and older and who weigh at least 77 lbs (35 kg) who:
    • have never taken HIV medicines before, and
    • have an amount of HIV-1 in their blood (this is called ‘viral load’) that is no more than 100,000 copies/mL
  • oral VOCABRIA (cabotegravir) for short term treatment of HIV-1 infection in adults when their healthcare professional determines that they meet certain requirements

HIV-1 is the virus that causes AIDS (Acquired Immune Deficiency Syndrome).

If you take EDURANT® in combination with oral VOCABRIA (cabotegravir), you should also read the Patient Information that comes with oral VOCABRIA (cabotegravir).

It is not known if EDURANT® is safe and effective in children less than 12 years of age or who weigh less than 77 lbs (35 kg).

Important Safety Information

Who should not take EDURANT®?

Do not take EDURANT® if you also take:

  • anti-seizure medicines:
    • carbamazepine
    • oxcarbazepine
    • phenobarbital
    • phenytoin
  • anti-tuberculosis (anti-TB) medicines:
    • rifampin
    • rifapentine
  • proton pump inhibitor (PPI) medicine for certain stomach or intestinal problems:
    • esomeprazole
    • lansoprazole
    • omeprazole
    • pantoprazole sodium
    • rabeprazole
  • more than 1 dose of the steroid medicine dexamethasone or dexamethasone sodium phosphate
  • St. John’s wort (Hypericum perforatum)
  • What should I tell my healthcare professional before taking EDURANT®?

    Before taking EDURANT®, tell your healthcare professional about all your medical conditions, including if you:

  • have or had liver problems, including hepatitis B or C virus infection
  • have kidney problems
  • have ever had a mental health problem
  • are pregnant or plan to become pregnant. It is not known if EDURANT® will harm your unborn baby. Tell your healthcare professional if you become pregnant during treatment with EDURANT®
  • are breastfeeding or plan to breastfeed. Do not breastfeed if you take EDURANT®
    • You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.
    • It is not known if EDURANT® passes into your breast milk. Talk with your healthcare professional about the best way to feed your baby during EDURANT® treatment.

Tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Some medicines interact with EDURANT®. Keep a list of your medicines to show your healthcare professional and pharmacist when you get a new medicine. You can ask your healthcare professional or pharmacist for a list of medicines that interact with EDURANT®.

Do not start taking a new medicine without telling your healthcare professional. Your healthcare professional can tell you if it is safe to take EDURANT® with other medicines.

How should I take EDURANT®?

  • Take EDURANT® every day exactly as your healthcare professional tells you to.
  • Take EDURANT® 1 time each day with a meal. A protein drink alone does not replace a meal.
  • Do not change your dose or stop taking EDURANT® without first talking with your healthcare professional. Stay under the care of your healthcare professional during treatment with EDURANT®.
  • Do not miss a dose of EDURANT®.
  • If you take an H2-receptor antagonist (famotidine, cimetidine, nizatidine, or ranitidine), you should take these medicines at least 12 hours before or at least 4 hours after you take EDURANT®.
  • If you take antacids, or other products that contain aluminum, calcium carbonate, or magnesium hydroxide, you should take these medicines at least 2 hours before or at least 4 hours after you take EDURANT®.
  • If you miss a dose of EDURANT® within 12 hours of the time you usually take it, take your dose of EDURANT® with a meal as soon as possible. Then, take your next dose of EDURANT® at the regularly scheduled time. If you miss a dose of EDURANT® by more than 12 hours of the time you usually take it, wait and then take the next dose of EDURANT® at the regularly scheduled time.
  • Do not take more than your prescribed dose to make up for a missed dose.
  • If you take too much EDURANT®, call your healthcare professional or go to the nearest hospital emergency room right away.
  • When your supply of EDURANT® starts to run low, get more from your healthcare professional or pharmacy. It is important not to run out of EDURANT®. The amount of HIV in your blood may increase if the medicine is stopped even for a short time.
  • When your healthcare professional prescribes use of EDURANT® with oral VOCABRIA (cabotegravir):
    • Take EDURANT® and oral VOCABRIA (cabotegravir) once a day at approximately the same time with a meal.
    • You will receive treatment with EDURANT® tablets in combination with oral VOCABRIA (cabotegravir) tablets for one month (at least 28 days) before you receive the long-acting medicine called CABENUVA (cabotegravir; rilpivirine extended-release injectable suspensions) for the first time. This will allow your healthcare professional to assess how well you tolerate these medicines.
    • Your final dose of EDURANT® and oral VOCABRIA should be taken on the same day you receive your first CABENUVA injections.
  • What are the possible side effects of EDURANT®?

    EDURANT® can cause serious side effects including:

  • Severe skin rash and allergic reactions. Skin rash is a common side effect of EDURANT®. Skin rash can be serious. Call your healthcare professional right away if you get a rash. In some cases, rash and allergic reaction may need to be treated in a hospital.

    If you get a rash with any of the following symptoms, stop taking EDURANT® and get medical help right away:

    • fever
    • skin blisters
    • mouth sores
    • redness or swelling of the eyes (conjunctivitis)
    • swelling of the face, lips, mouth, tongue, or throat
    • trouble breathing or swallowing
    • pain on the right side of the stomach (abdominal) area
    • dark-colored urine “tea colored”

  • Change in liver enzymes. People with a history of hepatitis B or C virus infection or who have certain liver function test changes may have an increased risk of developing new or worsening liver problems during treatment with EDURANT®. Liver problems have also happened during treatment with EDURANT® in people without a history of liver disease. Your healthcare professional may need to do tests to check your liver enzymes before and during treatment with EDURANT®.
  • Depression or mood changes. Tell your healthcare professional right away if you have any of the following symptoms:
    • feeling sad or hopeless
    • feeling anxious or restless
    • have thoughts of hurting yourself (suicide) or have tried to hurt yourself
  • Changes in body fat can happen in people who take HIV medicine. These changes may include increased amount of fat in the upper back and neck (“buffalo hump”), breast, and around the middle of your body (trunk). Loss of fat from the legs, arms, and face may also happen. The exact cause and long-term health effects of these problems are not known.
  • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your healthcare professional right away if you start having any new symptoms after starting your HIV-1 medicine.

The most common side effects of EDURANT® include depression, headache, trouble sleeping (insomnia), and rash.

This is not a complete list of all side effects. If you experience these or other symptoms, contact your healthcare professional right away.

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/ medwatch, or call 1-800-FDA-1088. You may also report side effects to Janssen Products, LP, at 1-800-JANSSEN (1-800-526-7736).

Please read the full Product Information in PDF format for more details.

cp-51056v3
+

What is EDURANT® (rilpivirine)?

EDURANT® is a prescription medicine that is used with:

  • other antiretroviral medicines to treat Human Immunodeficiency Virus (HIV-1) in people 12 years of age and older and who weigh at least 77 lbs (35 kg) who:
    • have never taken HIV medicines before, and
    • have an amount of HIV-1 in their blood (this is called ‘viral load’) that is no more than 100,000 copies/mL
  • oral VOCABRIA (cabotegravir) for short term treatment of HIV-1 infection in adults when their healthcare professional determines that they meet certain requirements

HIV-1 is the virus that causes AIDS (Acquired Immune Deficiency Syndrome).

If you take EDURANT® in combination with oral VOCABRIA (cabotegravir), you should also read the Patient Information that comes with oral VOCABRIA (cabotegravir).

It is not known if EDURANT® is safe and effective in children less than 12 years of age or who weigh less than 77 lbs (35 kg).